| ncRNA name | hsa-miR-145 |
| ncRNA Category | miRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human retinal endothelial cells |
| Methods | transfection, qRT-PCR, Western blot, cell apoptosis analysis, intracellular ROS analysis, luciferase reporter assay |
| Expression pattern | down-regulated |
| Functional description | Overexpression of miR-145 attenuated the HG induced apoptosis, oxidative stress and inflammatory ncytokines secretion in RECs. Besides, miR-145 overexpression also attenuated the mincreased TLR4 expression and NF-κB p65 nuclear translocation in HG-treated RECs. Luciferase reporter assay showed that miR-145 could specifically bind to the 3'UTR of TLR4. |
| PubMed ID | 29883722 |
| Year | 2018 |
| Title | MicroRNA-145 attenuates high glucose-induced oxidative stress and inflammation in retinal endothelial cells through regulating TLR4/NF-κB signaling |
| Drug-related ncRNA | NO |
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